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Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Trial


80% of ICD and CRT-D patients came from the same place.The COMPANION trial is the largest heart failure device trial to date. The trial shows that cardiac resynchronization therapy (CRT),
used in combination with optimal pharmacologic therapy (OPT), can significantly improve both the quality and duration of life for a large group
of heart failure patients.

The COMPANION trial followed more than 1500 heart failure patients from 128 US centers.

The trial yielded impressive results:

A pacemaker with CRT capabilities (CRT-P), in combination with OPT, reduced the risk of all-cause mortality or first hospitalization* by 19% when compared with OPT alone.1
A defibrillator with CRT capabilities (CRT-D), in combination with OPT, reduced the risk of all-cause mortality or first hospitalization* by 20% when compared with OPT alone.2
CRT-D, in combination with OPT, reduced the risk of all-cause mortality by 36% when compared with OPT alone.3

The COMPANION trial results are published in the May 20 issue of The New England Journal of Medicine. View and print article »

* Hospitalization is defined as either care provided at a hospital for any reason in which the duration is associated with a date change, or use of intravenous inotropes and/or vasoactive drugs for a duration > 4 hours (inpatient or outpatient). NOTE: Hospitalizations associated with a device implant attempt or re-attempt are excluded.

  1. Adjusted P value 0.015.
  2. Adjusted P value 0.011.
  3. Adjusted P value 0.004. P values adjusted for sequential monitoring.
    Alpha allocation: CRT-P = 0.02; CRT-D = 0.03.
COMPANION trial results

New MADIT-II Interviews with Key Contributors Posted on HRS Website »


OTHER RESOURCES
View and print The New England Journal of Medicine article

New expanded indication for Boston Scientific CRT-Ds

FDA Approves COMPANION Indication

COMPANION Trial At a Glance

Slideset: Results 2004 (PPT format in a ZIP archive, 1.1 MB) (Note: Slideset also available in PDF format on the University of Colorado Cardiovascular Institute website)

COMPANION and MADIT II: An Overview

CRT Cost-Effectiveness in COMPANION