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MADIT II

Economic Overview of Implantable Cardioverter Defibrillator (ICD) Therapy

As the benefits of prophylactic ICD therapy become increasingly evident, a significant increase in its use is expected. Both medical professionals and healthcare authorities have expressed concern over whether increased use of ICDs could disproportionately increase national healthcare expenditures (NHE). These concerns are mitigated by examining increased ICD therapy use within the context of total NHE costs and as it compares in cost-effectiveness with other lifesaving therapies.

In truth, even if the use of ICD therapy were to triple, it would still account for less than one half of 1% of the current total NHE.1 By 2005, a tripling of ICD usage would mean that only 0.4% of total NHE would be represented by ICD therapy.2

In fact, cost-effectiveness analyses have shown that prophylactic ICD therapy compares favorably with other lifesaving interventions. Utilizing a cost comparison including such factors as number of hospitalizations, follow-up treatments, and number of invasive procedures, several studies have determined that the cost-effectiveness of prophylactic ICD therapy is well within the currently accepted range of lifesaving technologies.3-5

One study, in fact, concluded that prophylactic ICD therapy becomes increasingly cost-effective when it is used early, as first-choice therapy in post-myocardial infarction (MI) patients with ventricular tachycardia (VT) or ventricular fibrillation (VF).5 Costs in this study were higher for the early ICD group only during the first 3 months. The early ICD group subsequently required fewer therapy changes and arrhythmia surgeries than a group initiated with other treatments.5

Using cost per life-year saved as a standard measure, ICD therapy may be as cost-effective, if not more so, than other life-saving interventions.3,4

Nominal Impact on National Healthcare Expenditures



Economic Impact on Life-Years Saved



References

  1. HCFA National Health Expenditures Projections 2000-2010.
  2. Data on file. Guidant Corporation
  3. Kupersmith J, Holmes-Rovner M, Hogan A, Gardiner J. Cost-effectiveness analysis in heart disease, part III: ischemia, congestive heart failure, and arrhythmias. Prog Cardiovasc Dis. 1995;37:307-346.
  4. Kuppermann M, Luce BR, McGovern B, Podrid PJ, Bigger T Jr, Ruskin JN. An analysis of the cost effectiveness of the implantable defibrillator. Circulation. 1990;81:91-100.
  5. Wever EFD, Hauer RNW, Schrijvers G, et al. Cost-effectiveness of implantable defibrillator as first-choice therapy versus electrophysiologically guided, tiered strategy in postinfarct sudden death survivors: a randomized study. Circulation. 1996;93:489-496.
  6. Moss AJ, Zareba W, Hall WJ, et al, for the Multicenter Automatic Defibrillator Implantation Trial II Investigators. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med. 2002;346:877-883.
  7. Myerburg RJ. Sudden cardiac death: exploring the limits of our knowledge. J Cardiovasc Electrophysiol. 2001;12:369-381.
  8. Moss AJ, Cannom DS, Daubert JP, et al, for the MADIT II Investigators. Multicenter Automatic Defibrillator Implantation Trial II (MADIT II): design and clinical protocol. Ann Noninvasive Electrocardiol. 1999;4:83-91.
  9. Kuppermann M, Luce BR, McGovern B, et al. An analysis of the cost effectiveness of the implantable defibrillator. Circulation. 1990;81:91-100

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